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EEG Biomarkers provide objective and functional measures of brain function and can be used to evaluate drugs efficacy or to phenotype a disease model.
This discovery, which combined Motac’s disease modeling and SynapCell’s EEG phenotyping capabilities, has been presented in a scientific communication during the SfN’s Neuroscience 2019 Annual Meeting in Chicago.
BetaPark is a translational EEG biomarker recorded in the motor cortex of both PD patients and animal models of prodromal and late-onset PD. Suppressed by dopaminergic drugs, BetaPark is used to quantify the efficacy of...
Auditory Steady-State Response (ASSR) is a translational EEG biomarker of the brain’s ability to process sensory information. 40Hz ASSR responses are specifically lowered in patients and rodent models of schizophrenia, making it relevant to evaluate...
Mesio-temporal lobe epilepsy (MTLE) represents one of the most common forms of focal epilepsies. Generally resistant to most pharmacological treatments, this type of epilepsy affects about 10% of the total epileptic population.
Patients with Absence Epilepsy show generalized, non-convulsive seizures & typical Spike-and-Wave Discharges. The GAERS model displays spontaneous SWD and recapitulates most human disease features, making it clinically-relevant to evaluate new drugs for Absence Epilepsy.
Phase-amplitude coupling can help study the interactions between neuronal oscillations. It describes a phenomenon whereby the amplitude of higher frequency activity is modulated by the phase of lower frequency activity, providing relevant information on Brain...
Event-related potentials are defined as the modification of the electrical activity of the nervous system in response to an external stimulation.