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Why Preclinical EEG Biomarkers?

EEG Biomarkers provide objective and functional measures of brain function and can be used to evaluate drugs efficacy or to phenotype a disease model.

GammaPark

L-DOPA-induced Dyskinesia (LID) are motor side-effects affecting PD patients chronically-treated with this dopamine replacement drug. Since LID are associated with aberrant Gamma cortical synchrony (GammaPark), efficacy of compounds on LID can be assessed with this...

SynapCell and Motac Neuroscience Discover New Biomarker of Parkinson’s Disease Progression!

This discovery, which combined Motac’s disease modeling and SynapCell’s EEG phenotyping capabilities, has been presented in a scientific communication during the SfN’s Neuroscience 2019 Annual Meeting in Chicago.

BetaPark – Translational EEG Biomarker

BetaPark is a translational EEG biomarker recorded in the motor cortex of both PD patients and animal models of prodromal and late-onset PD. Suppressed by dopaminergic drugs, BetaPark is used to quantify the efficacy of...

ASSR – Auditory Steady-State Response

Auditory Steady-State Response (ASSR) is a translational EEG biomarker of the brain’s ability to process sensory information. 40Hz ASSR responses are specifically lowered in patients and rodent models of schizophrenia, making it relevant to evaluate...

HPD – Hippocampal Paroxysmal Discharges

Mesio-temporal lobe epilepsy (MTLE) represents one of the most common forms of focal epilepsies. Generally resistant to most pharmacological treatments, this type of epilepsy affects about 10% of the total epileptic population.

SWD – Spike-and-Wave Discharges

Patients with Absence Epilepsy show generalized, non-convulsive seizures & typical Spike-and-Wave Discharges. The GAERS model displays spontaneous SWD and recapitulates most human disease features, making it clinically-relevant to evaluate new drugs for Absence Epilepsy.

PAC – Phase Amplitude Coupling

Phase-amplitude coupling can help study the interactions between neuronal oscillations. It describes a phenomenon whereby the amplitude of higher frequency activity is modulated by the phase of lower frequency activity, providing relevant information on Brain...

AERP – Auditory Evoked Event-Related Potentials

Event-related potentials are defined as the modification of the electrical activity of the nervous system in response to an external stimulation.

Cavion and SynapCell Present Significant Seizure-Suppressing Outcomes Using the GAERS Rat

Welcome to synapcell blog Cavion and SynapCell Present Significant Seizure-Suppressing Outcomes Using the GAERS Rat Cavion’s T-Type Calcium Channel Modulator CX-8998 is Superior to Current Standard of Care in Suppressing Absence Seizures in SynapCell’s Genetic...

Pfizer and SynapCell Present Major Preclinical Efficacy Results Using the GAERS

Pfizer has developed PF-06372865 a new subtype-selective GABAA positive allosteric modulator, and selected SynapCell for the preclinical in vivo evaluation of the antiepileptic potential of its compound.

New Perspectives for SynapCell

SynapCell is accelerating its growth by moving into new premises where all its activities have been brought together.

Today is the international Epilepsy Day

An epileptic disorder is a chronic neurological condition characterized by recurrent epileptic seizures. Epileptic seizures are characterized by a hypersynchrony and hyperexcitability of one, or several, neural networks, leading to the apparition of spontaneous epileptiform...